THE PROBABILISTIC DETERMINATION OF IDENTITY-BY-DESCENT SHARING FOR PAIRS OF RELATIVES FROM PEDIGREES
- 1 November 1990
- journal article
- research article
- Vol. 47 (5) , 842-853
Abstract
Methods for detecting genetic linkage are more powerful when they fully use all of the data collected from pedigrees. We first discuss a method for obtaining the probability that a pedigree member has a given genotype, conditional on the phenotypes of his relatives. We then develop a rapid method to obtain the conditional probabilities of identity-by-descent sharing of marker alleles for all related pairs of individuals from extended pedigrees. The method assumes that the individuals are noninbred and that the relationship between genotype and phenotype is known for the marker locus studied. The probabilities of identity-by-descent sharing among relative pairs, conditional on marker phenotype information, can then be used in any of the model free tests for linkage between a trait locus and a marker locus.This publication has 18 references indexed in Scilit:
- LINKAGE STRATEGIES FOR GENETICALLY COMPLEX TRAITS .3. THE EFFECT OF MARKER POLYMORPHISM ON ANALYSIS OF AFFECTED RELATIVE PAIRS1990
- THE POWER OF IDENTITY-BY-STATE METHODS FOR LINKAGE ANALYSIS1990
- THE AFFECTED-PEDIGREE-MEMBER METHOD OF LINKAGE ANALYSIS1988
- The affected sib-pair method using identity by state relations.1986
- A polymorphic DNA marker genetically linked to Huntington's diseaseNature, 1983
- Disease Susceptibility Genes ‐ their Identification by Multiple Case Family StudiesTissue Antigens, 1976
- Evidence for HL-A-linked genes in "juvenile" diabetes mellitus.BMJ, 1975
- The investigation of linkage between a quantitative trait and a marker locusBehavior Genetics, 1972
- A General Model for the Genetic Analysis of Pedigree DataHuman Heredity, 1971
- [The concept of identity and its importance in genetics].1966