Inhibitory Effect of Early Postnatal Injections of Cortisone Acetate on Vaginal Mitotic Activity in Neonatally Estrogenized, Ovariectomized Adult Mice

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Abstract
The epithelium lining the vaginae of adult C57 Black/Tw mice which had received injections of 20μg estradiol for 10 days from the day of birth exhibited continued proliferation and cornification. The states of the vagina were estrogen-independent, not being affected by ovariectomy. The effects of neonatal estradiol injections on the vagina were greatly impaired by injections of 20μg cortisone acetate given for 10 days commencing on the third or fourth postnatal day, as evidenced by marked reduction in the mitotic activity and proliferation of vaginal epithelial cells in ovariectomized adult mice which had been treated with the two steroids.