The Influence of Post-irradiation Conditions on the Survival of Chinese Hamster Cells after Gamma-irradiation
- 1 January 1970
- journal article
- research article
- Published by Taylor & Francis in International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine
- Vol. 17 (6) , 515-526
- https://doi.org/10.1080/09553007014550651
Abstract
Chinese hamster cells were exposed to a variety of treatments after gamma-irradiation. When DNA or protein synthesis was inhibited, there was no effect on survival. There was also no effect on survival from a reduction of temperature or the addition of caffeine. Actinomycin D, acriflavine, and ethidium bromide, which have the property of binding to nucleic acids, brought about a reduction in survival. It is suggested that the activity of any enzymes which repair radiation lesions in nucleic acids is impeded in a steric manner by the resulting complexes.Keywords
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