Comparative Inhibition of Anaphylaxis in Mice by Steroids, Tranquilizers and Other Drugs

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Abstract
The physiological mechanisms involved in anaphylaxis were further investigated by studies of drugs with adrenolytic, hypertensive, vasoconstrictive action, also tranquilizers and antihistaminics, diuretics, anti-inflammatory agents and newly available steroids. Mice were sensitized with normal horse serum. All drugs were administered prior to challenge and protection gauged by survival of sensitized mice compared with incidence of fatal anaphylaxis in untreated sensitized mice. Compounds exerting maximum protection were chlorpromazine, promazine, reserpine, lysergic acid diethylamide, prednisolone, prednisone, fluorohydrocortisone, hydrocortisone and cortisone. Inactive compounds were meprobamate, sedatives and antihistaminics, inflammatory agents, diuretics and predominantly sodium-retaining steroids.

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