Phorbol ester-induced regulation of transferrin receptors in human leukemia K562 cells.
- 31 December 1985
- journal article
- research article
- Published by Japan Society for Cell Biology in Cell Structure and Function
- Vol. 11 (2) , 181-190
- https://doi.org/10.1247/csf.11.181
Abstract
The treatment of human leukemia K562 cells with 12-O-tetradecanoyl phorbol-13-acetate (TPA) caused a decrease of transferrin receptors. The mechanism of the decrease of the receptors with TPA has been investigated. In cell incubated with TPA, the rate of biosynthesis of transferrin receptors was reduced to 10-20% of that in untreated cells. Pulse-chase experiments showed that turnover of the receptors in TPA-treated cells was accelerated over that in untreated cells. These results indicated that the decrease of transferrin receptors in TPA-treated cells was caused by reduced biosynthesis and accelerated degradation of the receptors.This publication has 35 references indexed in Scilit:
- Radioimmunochemical measurement of the transferrin receptor in human trophoblast and reticulocyte membranes with a specific anti-receptor antibody.Proceedings of the National Academy of Sciences, 1981
- Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin.Proceedings of the National Academy of Sciences, 1981
- Human cell surface glycoprotein related to cell proliferation is the receptor for transferrin.Proceedings of the National Academy of Sciences, 1981
- EARLY CHANGES IN PHOSPHATIDYLCHOLINE METABOLISM IN HUMAN ACUTE PROMYELOCYTIC LEUKEMIA-CELLS STIMULATED TO DIFFERENTIATE BY PHORBOL ESTER1981
- Human promyelocytic leukemia cells in culture differentiate into macrophage-like cells when treated with a phorbol diester.Proceedings of the National Academy of Sciences, 1979
- Induction of Differentiation in Human Promyelocytic Leukemia Cells by Tumor PromotersScience, 1979
- Biologically active phorbol esters specifically alter affinity of epidermal growth factor membrane receptorsNature, 1979
- Induction of terminal differentiation in human promyelocytic leukemia cells by tumor-promoting agents.Proceedings of the National Academy of Sciences, 1979
- Modulation of cell surface iron transferrin receptors by cellular density and state of activationJournal of Supramolecular Structure, 1979
- Tumor-Promoting Phorbol Esters Inhibit Binding of Epidermal Growth Factor to Cellular ReceptorsScience, 1978