Different Responses Elicited in Vitro by Antibodies to IgM and IgD in Cells from a Surface IgM + D‐Positive Human Follicular Lymphoma

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Abstract
The effect of anti‐Igs in combination with the tumour promoter TPA on DNA and Ig synthesis in a human follicular germinal centre cell lymphoma carrying slgM and slgD was investigated. The lymphoma cells responded to both amiti‐μ and anti‐γ chains and to anti‐δ light chains by DNA synthesis, as measured by mcthy‐(3H)‐thymidine incorporation. Flow cytofluorometric measurements, however, showed that only anti‐μ chains induced marked increase in cytoplasmic Ig content. This result suggests that in certain B‐cell subsets the signals elicited via slgM and slgD are different.