5‐Hydroxytryptamine1AReceptor Agonists in Animal Models of Depression and Anxiety
- 1 July 1992
- journal article
- Published by Wiley in Basic & Clinical Pharmacology & Toxicology
- Vol. 71 (1) , 24-30
- https://doi.org/10.1111/j.1600-0773.1992.tb00515.x
Abstract
The effects of different doses of buspirone, 3‐dipropyl‐amino‐5‐hydrochromar (NDO 008) and 8‐hydroxydipropyl‐aminotetralin (8‐OH‐DPAT) (administered intraperitoneally) were studied in tests of anxiolytic and antidepressant action in rats. These tests included the elevated plus maze test, the forced swim test, stress‐induced suppression of open‐field behavior, and the differential‐reinforcement‐of‐low‐rates‐of‐behaviour‐72 sec (DRL 72 s) test. Buspirone (0.125 mg/kg) and NDO 008 (1.0 to 2.0 mg/kg) produced anxiolytic activity in the elevated plus maze, whereas 8‐OH‐DPAT did not in the doses employed. All three compounds increased activity in the forced swim test, although buspirone did so at a lower dose than NDO 008 and 8‐OH‐DPAT. In the stress‐induced suppression test of open field activity all three compounds induced an antidepressant‐like effect at different doses dependent on whether footshock (stressor) was presented 24 hr before or just prior to the open‐field test. All three compounds even caused some reduction of activity in the non‐shocked rats. 8‐OH‐DPAT (1.0 mg/kg) produced a significant and reliable increase in the Reinforcement/Response rate quotient in the DRL 72s test. These diverse results may provide an indication of potential clinical efficacy of the 5‐HT1Aagonists in the treatment of anxiety and depression.Keywords
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