Intravenous cholecystokinin octapeptide: its effect on the sonographic appearance of the file ducts in normal subjects.

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Abstract
The response of the common hepatic duct to an i.v injection of sincalide (0.04 mcg/kg over 1 min) was assessed in 15 healthy volunteers. Ultrasound examinations performed at 5-min intervals for 1 h revealed a mean maximal decrease in gallbladder volume of 59%. The internal diameter of the duct was unchanged in 13 of 15 subjects and decreased by 1 mm in the remaining 2 subjects. Evidently, in normal subjects, there is no significant change in the internal diameter of the common hepatic duct in response to an i.v. dose of sincalide sufficient to effect gallbladder contraction.