The Effect of Graded, Single Doses of Busulfan on Murine Erythropoiesis

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Abstract
The effect of busulfan on murine erythropoiesis was studied following doses ranging from 10 to 100 mg/kg. The degree of depression of erythropoiesis was directly proportional to the dose of busulfan, as measured by hematocrit changes or by uptake of radioactive iron by spleen and marrow. The pattern of postbusulfan erythropoiesis was different from that seen after sublethal doses of whole body irradiation in some respects in that an abortive wave of erythropoiesis occurred in both marrow and spleen prior to onset of a more substantially sustained erythropoietic recovery. The pattern was like that following radiation in that the degree of reduction of erythropoiesis was directly related to dose as was the interval of time prior to onset of final recovery. In the spleen, this interval was 1 day per 20 mg/kg and in the marrow 0.5 days per 20 mg/kg.