Two Unusual Human Immunoglobulin VκGenes
- 1 January 1988
- journal article
- research article
- Published by Walter de Gruyter GmbH in Biological Chemistry Hoppe-Seyler
- Vol. 369 (2) , 601-608
- https://doi.org/10.1515/bchm3.1988.369.2.601
Abstract
The V.kappa. genes A10 and A14 which have been previously localized within the human .kappa. locus were analyzed now. A10 hybridizes under stringent conditions only weakly or not at all to probes characteristic for the four V.kappa. subgroups. According to their DNA sequences and the derived amino-acid sequences A10 and A14 do not fit well into the subgroup classification. They seem to be about as closely related to the subgroup I and III genes and less related to those of subgroups II and IV. Hybridization experiments indicate that A10 and A14 belong to a small V.kappa. gene family. After discussing the various features of the sequences we suggest neither to assign A10 and A14 to one of the existing subgroups nor to establish a new one but to apply to them the subgroup designation N which may be changed when all V.kappa. genes are known and can be classified together.This publication has 6 references indexed in Scilit:
- The human VK locusJournal of Molecular Biology, 1988
- The human Vκ locusJournal of Molecular Biology, 1987
- Direct evidence for chromosomal inversion during T-cell receptor β-gene rearrangementsNature, 1986
- A large section of the gene locus encoding human immunoglobulin variable regions of the Kappa type is duplicatedJournal of Molecular Biology, 1985
- Organization and evolution of a gene cluster for human immunoglobulin variable regions of the kappa typeJournal of Molecular Biology, 1984
- Differences between germ-line and rearranged immunoglobulin Vκ coding sequences suggest a localized mutation mechanismNature, 1981