Inverse Effects of Purified Hypothalamic TRF on the Acute Secretion of TSH and ACTH

Abstract
When the pituitary is induced to secrete TSH (thyroid stimulating hormone) by TRF (thyrotropin) it concomitantly secretes less ACTH in response to stress; conversely, when the secretion of ACTH is inhibited as by pretreatment with dexamethasone and Nembutal, the pituitary secretes higher quantities of TSH in response to TRF.