PASSIVE TRANSFER OF VIRUS INDUCED DIABETES MELLITUS WITH SPLEEN CELLS
- 1 November 1978
- journal article
- research article
- Published by Wiley in Acta Pathologica Microbiologica Scandinavica Section C Immunology
- Vol. 86C (1-6) , 29-32
- https://doi.org/10.1111/j.1699-0463.1978.tb02553.x
Abstract
The study describes passive transfer of diabetes mellitus by transplantation of spleen cells from donor mice infected with a diabetogenic encephalomyocarditis virus. Inbred normal C57 mice were used as both donors and recipients, and other recipients were C57 athymic, nude mice. Transplants were made in two series after 12 and 22 days duration of infection of the donors, respectively. All recipients became diabetic. The possibility of virus transfer with the spleen cell transplant is discussed, and found to be highly improbable. The fact that passive cellular transfer can be effected points to a decisive significance of the thymus dependent lymphocyte system in the pathogenesis of the primary diabetes.Keywords
This publication has 3 references indexed in Scilit:
- THE INABILITY OF A DIABETOGENIC VIRUS TO INDUCE DIABETES MELLITUS IN ATHYMIC (NUDE) MICEActa Pathologica Microbiologica Scandinavica Section C Immunology, 2009
- PASSIVE TRANSFER OF STREPTOZOTOCIN INDUCED DIABETES MELLITUS WITH SPLEEN CELLSActa Pathologica Microbiologica Scandinavica Section C Immunology, 1977
- Diabetes Mellitus: Induction in Mice by Encephalomyocarditis VirusScience, 1968