PASSIVE TRANSFER OF STREPTOZOTOCIN INDUCED DIABETES MELLITUS WITH SPLEEN CELLS
- 1 December 1977
- journal article
- research article
- Published by Wiley in Acta Pathologica Microbiologica Scandinavica Section C Immunology
- Vol. 85C (6) , 469-472
- https://doi.org/10.1111/j.1699-0463.1977.tb03670.x
Abstract
This study shows passive transfer of streptozotocin induced diabetes mellitus in mice. Transplants of spleen cells from BALB/c mice, streptozotocin treated for 5 days, induced diabetes in normal BALB/c recipients. Treatment of transplants with anti‐theta and complement resulted in a significant decrease in the degree of diabetes. Athymic nude mouse recipients of BALB/c background also developed diabetes after transplant of spleen cells from both syngenic and allogeneic (C57/B1/6) donors. It is concluded that passive transfer of chemically induced diabetes in mice is practicable, in both syngeneic and allogeneic combinations, and that thymus derived lymphocytes are significant in this process.Keywords
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