Analysis of urinary nucleosides. III. Identification of 5′‐deoxycytidine in urine of a patient with head and neck cancer

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Abstract
Modified nucleosides in the urine have been postulated to be diagnostic indices of disease, particularly of cancer. The urine of a patient with terminal head and neck cancer has been found to contain a modified nucleoside with a protonated molecule of m/z 228. By means of high-performance liquid chromatography/ion trap mass spectrometry (HPLC/ITMS) and capillary liquid chromatography/triple quadruple mass spectrometry (CapLC/TQMS) we have identified the compound as 5′-deoxycytidine. This is the first report of 5′-deoxycytidine in man: in addition to the elucidation of its structure, its possible origins and the potential significance of its occurrence are discussed. Copyright © 2003 John Wiley & Sons, Ltd.