INCREASED ACTIVITY OF RAT-LIVER MESSENGER-RNA AND OF ALBUMIN MESSENGER-RNA MODULATED BY THIOACETAMIDE
- 1 January 1978
- journal article
- research article
- Vol. 38 (7) , 2043-2047
Abstract
Administration of thioacetamide to rats increased the activity of liver mRNA in the wheat germ protein synthesis assay. The synthesis of total protein was increased about 2.5-fold after 4 days of treatment. Treatment was associated with an increase in the relative quantity of polyadenylic acid-containing RNA. Immunoprecipitation studies showed that albumin synthesis directed by the mRNA was increased disproportionately, reaching a level 5-6 times the control after 4 days of thioacetamide administration.This publication has 7 references indexed in Scilit:
- Use of molecular hybridization to purify and analyze albumin messenger RNA from rat liverProceedings of the National Academy of Sciences, 1977
- Alterations in DNA-dependent RNA polymerases I and II from rat liver by thioacetamide: preferential increase in the level of chromatin-associated nucleolar RNA polymerase IBBiochemistry, 1977
- Stimulation of in Vitro Translation of Messenger RNA by Actinomycin D and CordycepinScience, 1977
- Rat liver preproalbumin: in vitro synthesis and partial amino acid sequence.Proceedings of the National Academy of Sciences, 1977
- Isolation of rat liver albumin messenger RNA.Journal of Biological Chemistry, 1976
- Selection of albumin mRNA by thioacetamideBiochemical and Biophysical Research Communications, 1976
- Physiology of rat-liver polysomes. Protein synthesis by stable polysomesBiochemical Journal, 1967