THE DISTRIBUTION OF ORALLY ADMINISTERED RADIO-ACTIVE METHYL-THIOURACIL IN COCKERELS

Publisher Website
Google Scholar
Abstract
Radioactive-S-labeled methylthiouracil was synthesized from Na2S* O4 and admd. orally with a carrier of inactive methylthiouracil to 15-wk.-old cockerels. Excreta and organs were ashed (250 mg. aliquots + 2 ml. HNO3 at 275[degree]C for 3 hrs.), the excess HNO3 removed by evaporation and the SO4 precipitated as BaSO4 and counted under a mica window counter. Within 24 hrs. after a single dose, most of the S* is excreted (60-70%); the rest is chiefly found in the thyroid, the bases of the feather shafts, and probably the pituitary, though quantities here are at the limit of counting accuracy. The thyroid accumulated approx. 10 times as much S* as the feathers. After repeated dosage there is a definite tendency to cumulation.
Keywords

This publication has 2 references indexed in Scilit: