Impaired lymphocyte responsiveness to phytohaemagglutinin associated with the possession of HLA‐B8/DR3

Abstract
An examination was made of blastogenic response to phytohaemagglutinin (PHA) in HLA‐B8 and/or DR3 positive subjects and B8/DR3 negative individuals. Both B8 and DR3 antigens were associated with a depression of the response at all three doses of PHA used. The possession of both these antigens did not lead to a further depression of the response.