Synthesis of L-Kynurenine peptides conducted without masking the side-chain amino group
- 1 January 1980
- journal article
- research article
- Published by CSIRO Publishing in Australian Journal of Chemistry
- Vol. 33 (3) , 633-640
- https://doi.org/10.1071/ch9800633
Abstract
Various free L-kynurenine peptides, including an analogue of the opiate agonist leucine-enkephalin, have been synthesized by using the Nα-t- butyloxycarbonyl derivative of L-kynurenine as a key precursor. By selecting appropriate mild conventional coupling procedures it was possible to carry out the synthetic operations without having to mask the side-chain amino group in any way, but intramolecular acylation with formation of a seven-membered lactam could be demonstrated under more vigorous conditions.Keywords
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