Complement Fixation by Tuberculopolysaccharide.

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Abstract
High complement fixation titers with PPD-S were obtained with BCG antisera which showed high precipitating antibodies to PPD-S and to tuberculopolysaccharide. Polysaccharide fixed no complement even in these sera when incubation was carried out at 37[degree]C. However, at 4[degree]C fixation did take place. When polysaccharide was mixed with PPD-S the complement-fixation titer was decreased from that obtained with the PPD-S alone, suggesting inhibition of fixation at 37[degree]C. However, this decrease appeared to be due to fixation by polysaccharide in the first stage, followed by a probable release of the complement to the red-blood-cell-amboceptor system in the second stage.