Does vitamin C act as a pro‐oxidant under physiological conditions?
- 1 June 1999
- journal article
- review article
- Published by Wiley in The FASEB Journal
- Vol. 13 (9) , 1007-1024
- https://doi.org/10.1096/fasebj.13.9.1007
Abstract
Vitamin C readily scavenges reactive oxygen and nitrogen species and may thereby prevent oxidative damage to important biological macromolecules such as DNA, lipids, and proteins. Vitamin C also re...Keywords
Funding Information
- National Institutes of Health (HL‐49954, HL‐56170)
This publication has 137 references indexed in Scilit:
- The Effects of Iron and Vitamin C Co-supplementation on Oxidative Damage to DNA in Healthy VolunteersBiochemical and Biophysical Research Communications, 1998
- Vitamin C supplementation on hepatic oxidative stress induced by cigarette smokeJournal of Applied Toxicology, 1997
- (−)-Epigallocatechin gallate, a polyphenolic tea antioxidant, inhibits peroxynitritemediated formation of 8-oxodeoxyguanosine and 3-nitrotyrosineCellular and Molecular Life Sciences, 1996
- Vitamin C prevents metal ion-dependent initiation and propagation of lipid peroxidation in human low-density lipoproteinBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1995
- SHORT COMMUNICATION: Effect of ascorbate and 5-aminosalicylic acid on light-induced 8-hydroxydeoxyguanosine formation in V79 Chinese hamster cellsCarcinogenesis: Integrative Cancer Research, 1993
- The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and AscorbateArchives of Biochemistry and Biophysics, 1993
- In vitro lipid peroxidation of human serum catalyzed by cupric ion: Antioxidant rather than prooxidant role of ascorbateLife Sciences, 1992
- Ascorbic acid safety: analysis of factors affecting iron absorptionToxicology Letters, 1990
- New Concepts in the Biology and Biochemistry of Ascorbic AcidNew England Journal of Medicine, 1986
- L-ascorbic acid quenching of singlet delta molecular oxygen in aqueous media: Generalized antioxidant property of vitamin CBiochemical and Biophysical Research Communications, 1983