CHEMICAL CHANGES IN EXPERIMENTAL RENAL HYPERTENSION

Publisher Website
Google Scholar
Abstract
The composition of heart and kidney tissue of normal rats, and of normotensive and hypertensive rats after partial constriction of one renal artery has been studied; the parameters included wet wt., water, protein, lipid, ash and residue. Wet wt. of the adrenal glands was also obtained. A sham flank operation did not alter the composition of either kidney or heart. All the constituents studied were equally distributed in the left and right kidneys. The hearts of hypertensive rats showed a decrease in the content of lipid and ash, a slight increase in water and slight hypertrophy. The total renal mass of the hypertensive animal was significantly decreased, the operated kidney accounting for most of the change. When operation did not induce hypertension, the total renal mass was unchanged; however, the operated kidney became atrophic and the opposite kidney hypertrophic. The lipid and ash contents of kidneys of both hypertensive and normotensive-operated animals increased, the change being limited to the operated kidney. The renal protein content of both hypertensive and normotensive-operated animals decreased, the changes occurring in the operated kidney and being especially large in the latter group. The adrenal mass of only the hypertensive rats was significantly increased.

This publication has 4 references indexed in Scilit: