And the Walls Come Tumbling Down

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Abstract
Little by little we are experiencing the erosion of the strongest bulwarks against serious bacterial infections in the modern antibacterial era. In 1955, I reviewed the extensive literature on the emergence of antibiotic-resistant bacteria,1 and more recently summarized some of the subsequent developments.2 Some highlights of these developments are worth noting.When the sulfonamide drugs were introduced they were widely and successfully used in the treatment of gonorrhea and of Group A hemolytic streptococcal infections. It was not long before the effectiveness of the sulfonamides against these infections was essentially lost. In gonorrhea, which is transmitted exclusively by person-to-person contact, . . .

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