Coefficient induction of pepsinogen 1-decreased pyloric glands and gastric cancers in five different strains of rats treated with N-methyl-N′-nitro-N-nitrosoguanidine

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Abstract
Sequential changes of numbers of pepsinogen 1 (Pg 1)-decreased pyloric glands (PDPG) detected by immunohistochemistry and of the incidence of gastric carcinomas were examined in five different strains of rats treated with N methyl- N '-nitro- N -nitrosoguanidine (MNNG;CAS:70–25–7). Male SD (Crj:CD), WKY (WKY/NCrj), Lewis (LEW/Crj), Wistar (Crj:Wistar) and E344 (F344/DuCrj) rats (40 per strain), were given drinking water containing 100 μg/ml MNNG for 30 weeks and thennormal tap water, and were killed at week 10, 30 and 50 of the experiment. Adenocarcinomas of the glandular stomach were found in nine of 15 SD rats (60%), in eight of 12 WKY rats (67%), in eight of 15 Lewis rats (53%), in three of 13 Wistar rats (23%) andin one of 18 F344 rats (6%) at week 50. These incidences of carcinomas in SD, WKY and Lewis were significantly higher (P < 0.01) than that in E344 rats. From week 10, the numbers of PDPG in SD, WKY and Lewis rats were significantly greater (P < 0.01) than that in K344 rats. From week 30, the numbers of PDPG in Wistar rats were also significantly greater (P < 0.05–0.01) than that of E344. The susceptibility of rats to induction of gastric carcinoma by MNNG correlated with the susceptibility to induction of PDPG by MNNG in each strain, suggesting that induction of PDPG is a preneoplastic change in chemical gastric carcinogenesis.

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