THE EFFECTS OF SILICA AND FLY-ASH DUST INHALATION ON ALVEOLAR MACROPHAGE EFFECTOR CELL-FUNCTION

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  • 1 January 1982
    • journal article
    • research article
    • Vol. 32  (6) , 449-459
Abstract
Inhalation of silica caused significant enhancement of alveolar macrophage, antibody-dependent, cell-mediated cytotoxicity (ADCC) after 14, 42 and 70 days of exposure [in Syrian Golden hamsters], while similar treatment using fly ash resulted in significant suppression of ADCC after 42 days of exposure. Silica and fly ash inhalation depressed the ability of alveolar macrophages from BCG-primed and BCG-rechallenged animals to mediate hamster SV40 cell lysis. Fly ash exposure also significantly suppressed the ability of BCG-activated macrophages to lyse target cells by the ADCC mechanism.