Studies of structure activity relationship of flavonoids for the anti-allergic actions
- 1 August 1998
- journal article
- other
- Published by Springer Nature in Archives of Pharmacal Research
- Vol. 21 (4) , 478-480
- https://doi.org/10.1007/bf02974647
Abstract
The structure activity relationship of flavonoids for anti-allergic actions was studied by determining the IC50 values for the degranulation. The hexosaminidase release from RBL-2H3 cells (degranulation marker) was employed as an estimate for the anti-allergic actions. Among 22 flavonoid compounds tested, luteolin, apigenin, diosmetin, fisetin, and quercetin were found to be most active with IC50 values less than 10 μM.Keywords
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