Various Natural and Modified Bile Acids in Cholesterol Metabolism

Publisher Website
Google Scholar
Abstract
A variety of bile acids was included in the diet of rats at 0.0098 moles per kg diet to evaluate their effect on the serum and liver cholesterol concentrations and on serum β-lipoprotein concentrations. A wide range of values was observed. Triformoxycholanic acid, triformoxycholanyl chloride, lithocholic acid, cholanic acid and 3 β-hydroxy Δ5-cholenic acid did not elevate the serum cholesterol level. The remaining 9 regimens resulted in varying degrees of elevation of serum and liver cholesterol values, but none was more active than cholic acid. Triformoxycholanic acid partially inhibited the action of cholic acid when both compounds were fed together. Triformoxycholanic acid was without significant effect on the serum cholesterol level of Cebus monkeys. Three α-, 7α-, 12α-triformoxycholanate-24-C14 was rapidly absorbed from the intestine and excreted into the bile as a conjugated (but uncharacterized) bile acid. The evidence suggesting that the configuration at position 12 is crucial to the serum- and liver-cholesterol-elevating properties of certain bile acids was discussed.