Effects of dose fractionation after irradiation with neutrons produced by 600 MeV protons

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Abstract
Biological effects produced by neutrons of various energies up to 15 MeV have been extensively studied through their use in therapeutic applications (Barendsen, 1968; Hall et al., 1973; Hornsey and Field, 1979). Possible further radiotherapeutic gains from neutrons of higher energies have been investigated recently (Harrison et al., 1976; Hall and Durand, 1980). Biological damage by neutrons with maximum energies of 400 and 600 MeV, produced by the CERN synchrocyclotron, have been investigated for several years. Un-expected effects were observed in the low-dose regions (Baarli et al., 1976; Di Paola et al., 1980; Diehl-Marshall and Bianchi, 1981).

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