Molecular Aspects of Systemic Lupus Erythematosus: Murine Endogenous Retroviral Expression
- 1 April 1992
- journal article
- review article
- Published by Mary Ann Liebert Inc in DNA and Cell Biology
- Vol. 11 (3) , 253-257
- https://doi.org/10.1089/dna.1992.11.253
Abstract
Systemic lupus erythematosus is an immune-mediated disease in which the etiology is unknown. Full-length (8.4 kb), type C, modified polytropic (Mpmv) retroviral transcripts from the thymus are characteristic of murine lupus. Reciprocal bone marrow transplantation studies determined that this thymic expression maps to the pre-T bone marrow stem cell. In vitro and in vivo oligonucleotide antisense work suggest that type C retroviruses play a role in immune activation. This paper summarizes our studies of endogenous retroviruses in murine lupus.Keywords
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