INTERCELLULAR COMMUNICATION CAPACITY AS A POSSIBLE DETERMINANT OF TRANSFORMATION SENSITIVITY OF BALB/C 3T3 CLONAL CELLS

  • 1 January 1985
    • journal article
    • research article
    • Vol. 45  (2) , 637-641
Abstract
While clonal cell variants of [mouse] BALB/c-3T3 with high and low susceptibilities to UV radiation- and benzo(a)pyrene-induced transformation show similar intercellular communication capacities when they are in the growing phase, a significant loss in communication occurs at confluence only in transformation-sensitive clonal variant cells. A potent tumor promoter, 12-O-tetradecanoylphorbol-13-acetate, which also enhances BALB/c-3T3 cells transformation induced by methylcholanthrene, inhibited intercellular communication of these variants to a similar extent. Intrinsic differences in the control of intercellular communication may be a determinant of the susceptibility of these variants to the induction of transformation.

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