A New Tumor-Promoting Agent, Dihydroteleocidin B, Markedly Enhances Chemically Induced Malignant Cell Transformation
- 30 April 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 216 (4545) , 527-529
- https://doi.org/10.1126/science.6280280
Abstract
Teleocidin, which was isolated from mycelia of Streptomyces, is a potent tumor promoter in mouse skin. The catalytically hydrogenated compound dihydroteleocidin B markedly enhanced malignant cell transformation induced by 3-methylcholanthrene or ultraviolet radiation. Dihydroteleocidin B was at least 100 times more effective in enhancing transformation than 12-O-tetradecanoyl phorbol-13-acetate, the strongest promoter known until now, whereas both promoters showed equal capacities to induce early membrane effects and DNA synthesis.This publication has 13 references indexed in Scilit:
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