Dissociation Between Free and Bound Phenytoin Levels in Presence of Valproate Sodium
- 1 April 1981
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 38 (4) , 240-242
- https://doi.org/10.1001/archneur.1981.00510040066011
Abstract
• A dissociation of free vs bound phenytoin levels is frequently observed in the presence of therapeutic doses of valproate sodium. This leads at times to symptoms and signs of phenytoin intoxication despite "therapeutic" plasma levels. The importance of supplementing bound levels with free levels is stressed when combined therapy of this type is used in epileptic patients.This publication has 1 reference indexed in Scilit: