Zur Biogenese der Alkaloide, III. Lysin als Vorstufe des Coniins

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Abstract
New procedures are described for the preparative isolation and the quantitative estimation of coniine from plant material. The coniine content of 0.1[long dash]10 g (micro-method) or 10[long dash]100 g (macromethod) of dry hemlock power can be determined titrimetrically or gravimetrically. The coniine content of hemlock was studied over the growth period, using this method. The amino acid content of Conium maculatum was studied qualitatively. Lysine and pipecolic acid were found, together with alanine, serine, glycine, glutamic acid, aspartic acid, valine, leucine and phenyllanine. Injection of generally labelled [C14]lysine into plants of different size gave radioactive coniine. The coniine of highest specific activity was isolated from the site of injection and the young, growing tissues. This indicates a rapid incorporation of lysine into coniine in growing tissues. Lysine is a precursor of the piperidine ring of coniine.

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