Vaginal Immunization Against Induced Cystitis in Monkeys
- 1 February 1987
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of Urology
- Vol. 137 (2) , 327-329
- https://doi.org/10.1016/s0022-5347(17)44015-8
Abstract
Cynomolgus monkeys received either vaginal immunization with formalin-killed Escherichia coli or vaginal instillation of excipient without the bacteria. At 2, 7, 14 and 21 days after induction of a urinary tract infection with live E. coli, immunized monkeys showed enhanced clearance of bacteriuria compared to non-immunized controls. Immunized monkeys also showed increased levels of urinary anti-E. coli IgA and IgG after the immunizing and infecting procedures. Induction of heightened local immunity by vaginal immunization may lessen host susceptibility to urinary tract infections.This publication has 15 references indexed in Scilit:
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