LYMPHOCYTE SURFACE IGD AND IGM IN MACACA MONKEYS - ONTOGENY, TISSUE DISTRIBUTION AND OCCURRENCE ON INDIVIDUAL LYMPHOCYTES

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 33  (6) , 865-872
Abstract
A proportion of lymphocytes in blood, spleen and lymph nodes of nonhuman primates [M. mulatta or M. arctoides] had immunoglobulin[Ig] on their surfaces detectable by florescent antibody to human IgM and IgD. The majority of the individual lymphocytes having IgM or IgD on their surfaces possessed both classes of Ig. Lymphocytes surface IgD was capped independently of surafce IgM on the same cell when incubated at 37.degree. C with anti-IgD. Lymphocytes with surface IgM and/or IgD were present in blood at birth and the percentages over the first 6 mo. of life were increased compared to older monkeys. A corona of cells faintly positive for IgM and IgD was observed around germinal centers of lymph nodes and spleen.