LYMPHOCYTE-B SUBSET PATTERNS AND THEIR SIGNIFICANCE IN IDIOPATHIC GLOMERULONEPHRITIS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 48  (1) , 201-204
Abstract
The proportion of B lymphocyte subsets with surface IgG (sIgG) was significantly increased in minimal change nephrotic syndrome (MCNS), membranous nephropathy, IgA nephropathy and mesangiocapillary glomerulonephritis (MCGN) and with sIgA in IgA nephropathy and MCGN, and with sIgE in MCNS. Increased subsets in membranous nephropathy, IgA nephropathy and MCGN corresponded to the Ig deposited in the glomeruli and the increased subset of sIgE in MCNS was correlated with the elevation of serum IgE. Each disease studied appears to have a characteristic pattern of B lymphocyte response. This may have an important role in determining the histological type of idiopathic glomerulonephritis.