Assembly and Trafficking of Heterotrimeric G Proteins
Top Cited Papers
- 9 June 2007
- journal article
- review article
- Published by American Chemical Society (ACS) in Biochemistry
- Vol. 46 (26) , 7665-7677
- https://doi.org/10.1021/bi700338m
Abstract
To be activated by cell surface G protein-coupled receptors, heterotrimeric G proteins must localize at the cytoplasmic surface of plasma membranes. Moreover, some G protein subunits are able to traffic reversibly from the plasma membrane to intracellular locations upon activation. This current topic will highlight new insights into how nascent G protein subunits are assembled and how they arrive at plasma membranes. In addition, recent reports have increased our knowledge of activation-induced trafficking of G proteins. Understanding G protein assembly and trafficking will lead to a greater understanding of novel ways that cells regulate G protein signaling.Keywords
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