REACTIONS OF THE CAT PIAL CIRCULATION TO HYPOTENSIVE STATES INDUCED BY HEXAMETHONIUM BROMIDE

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Abstract
SKULL window preparations have been used extensively since Forbes1 introduced a satisfactory technique whereby a small section of the pial vessels can be observed and accurately photographed without the embarrassment of vessel movement or the disadvantage of any disturbance of internal pressure arrangements. Such a preparation allows the detailed study of vascular changes in an important area and has the advantage of displaying those vessels contributing appreciably to the peripheral vascular resistance and thus most likely to show significant changes in any circulatory readjustments. Unfortunately, no capillary bed is demonstrable and only a small superficial area is exposed; but there is evidence to suggest that the pial vessels reflect accurately the direction of changes in the whole brain (Finesinger and Putnam2), and some idea of the reactions of the deeper cerebral vessels can be gained from alterations in the general color of the field. Direct observations on moving

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