The expression of surface antigens on three trophoblastic tissues in the mouse

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Abstract
The expression of paternal and maternal antigens [Ag] on 3 types of mouse trophoblast cultured in vitro was examined with the mixed hemadsorption test. Primary trophoblastic giant cells outgrown from blastocysts and placental trophoblast from 16-day pregnancies expressed Ag of both sources at all stages in culture. Secondary trophoblastic giant cells outgrown from the tip of 8-day ectoplacental cones did not give a positive reaction until they outgrew for 3-5 days. Microdensitometry after Feulgen staining showed that the cells which gave a positive mixed hemadsorption response were polyploid. Incubation of blastocysts and ectoplacental cone tissue with progesterone, estradiol-17.beta. and hCG [human chorionic gonadotropin] did not affect the results.