Complement-Dependent Neutralization of Transmissible Gastroenteritis Virus by Monoclonal Antibodies
- 1 January 1987
- book chapter
- Published by Springer Nature
- Vol. 218, 493-500
- https://doi.org/10.1007/978-1-4684-1280-2_64
Abstract
Monoclonal antibodies (MAb) to each of the 3 major structural proteins of transmissible gastroenteritis virus (TGEV) of swine were compared as to their virus neutralizing activity in the presence or absence of guinea pig complement. MAbs to the peplomer protein had neutralizing activity for TGEV with or without complement and the titers were similar in either case. MAbs to the matrix protein had neutralizing activity for TGEV only in the presence of complement. Antibodies to the nucleocapsid protein were without neutralizing activity with or without complement.Keywords
This publication has 9 references indexed in Scilit:
- Identification of a 17000 Molecular Weight Antigenic Polypeptide in Transmissible Gastroenteritis Virus-infected CellsJournal of General Virology, 1986
- Replication of Transmissible Gastroenteritis Coronavirus (TGEV) in Swine Alveolar MacrophagesJournal of General Virology, 1984
- Improvements in obtaining and characterizing mouse cerebrospinal fluid☆Application to mouse hepatitis virus-induced encephalomyelitisJournal of Neuroimmunology, 1983
- The Molecular Biology of CoronavirusesPublished by Elsevier ,1983
- Antigenic relationships among homologous structural polypeptides of porcine, feline, and canine coronavirusesInfection and Immunity, 1982
- Monoclonal antibodies to murine hepatitis virus-4 (strain JHM) define the viral glycoprotein responsible for attachment and cell-cell fusionVirology, 1982
- Antigenicity of structural components from porcine transmissible gastroenteritis virusVeterinary Microbiology, 1979
- The Neutralization of Transmissible Gastroenteritis Virus by Normal Heterotypic SerumJournal of General Virology, 1979