Acute renal failure. Association with administration of radiographic contrast material

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Abstract
Acute renal failure [14 cases] secondary to administration of radiographic contrast media were observed, 8 within a 15 mo. period. No patient had multiple myeloma, and 3 were diabetic. Predisposing factors included renal hypoperfusion, preexisting renal insufficiency, hyperuricemia, age of more than 60 yr, solitary functioning kidney and exposure to several contrast studies at closely spaced intervals. Control of blood volume and serum uric acid, appropriate spacing of radiographic studies and possibly urinary alkalinization and hypouricosuric drugs in high-risk patients are recommended to decrease the incidence and morbidity of contrast-mediated nephropathy.

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