Ile‐Ser‐bradykinin (T‐kinin) and Met‐Ile‐Ser‐bradykinin (Met‐T‐kinin) are released from T‐kininogen by an acid proteinase of granulomatous tissues in rats
- 27 July 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 219 (2) , 437-440
- https://doi.org/10.1016/0014-5793(87)80267-3
Abstract
An acid proteinase of granulomatous tissues in rats with carrageenin-induced inflammation released kinin from T-kininogen. The kinin isolated by n-butanol extraction was separated by reverse-phase high-performance liquid chromatography into T-kinin and a T-kinin derivative. From determination of its amino acid composition and its immunoreactivity toward anti-bradykinin antiserum, the T-kinin derivative was identified as Met-Ile-Ser-bradykinin (Met-T-kinin).Keywords
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