Fecal Flora in Recurrent Urinary-Tract Infection

Publisher Website
Google Scholar
Abstract
Successful treatment of urinary-tract infections in certain female patients is hindered by frequent recurrences caused by fecal bacteria. Nitrofurantoin alone and trimethoprim–sulfamethoxazole together are two recognized antimicrobial modes of therapy effective as prophylaxis for this problem. Stamey et al., in this week's issue of the Journal, present evidence that recurrent urinary-tract infection can be prevented by doses of trimethoprim–sulfamethoxazole lower than those customarily used. Furthermore, they show that the biologic mechanism of prophylaxis with the two-drug regimen is different. No one can speak of cure, but in this series, about half the treated patients remained free of recurrences six . . .