THE MECHANISM OF ACTION OF LITHOSPERMUM RUDERALE

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Abstract
L. ruderale was fed to normal and castrated animals. While it was found to decrease the gonadotrophin titer of the pituitaries of intact animals, no such dimunition was observed in the characteristically elevated gonadotrophin potency of the pituitaries of the castrated animals. The possibility of indirect action via the thyroids or a borderline deficiency of the vitamin B complex has been negated. The hypothesis of Lithospermum action by means of a specific inhibition of the production of the luteinizing hormone of the anterior pituitary is suggested.