Abstract
The addition of 0.5% EDTA to a cariogenic diet appeared to potentiate caries to a marked degree in the white rat. Concomitantly, the hematocrit value is significantly lowered and almost complete inhibition of incisor pigmentation is found. These effects of EDTA do not seem to be associated with its ability to decalcify rat molar teeth in vivo. Citrate and calgon added to a cariogenic diet and present in the drinking fluid do not significantly increase the severity of caries.

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