Synthesis and biological investigations of dopaminergic partial agonists preferentially recognizing the D4 receptor subtype
- 1 June 2006
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 16 (11) , 2955-2959
- https://doi.org/10.1016/j.bmcl.2006.02.075
Abstract
No abstract availableKeywords
This publication has 21 references indexed in Scilit:
- Discovery of 2-(4-Pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a Dopaminergic Agent with a Novel Mode of Action for the Potential Treatment of Erectile DysfunctionJournal of Medicinal Chemistry, 2004
- Drug Design Strategies for Targeting G-Protein-Coupled ReceptorsChemBioChem, 2002
- 2,4-Disubstituted pyrroles: synthesis, traceless linking and pharmacological investigations leading to the dopamine D4 receptor partial agonist FAUC 356Bioorganic & Medicinal Chemistry Letters, 2002
- Benzamide bioisosteres incorporating dihydroheteroazole substructures: EPC synthesis and SAR leading to a selective dopamine D4 receptor partial agonist (FAUC 179)Bioorganic & Medicinal Chemistry Letters, 2001
- Rationally Based Efficacy Tuning of Selective Dopamine D4 Receptor Ligands Leading to the Complete Antagonist 2-[4-(4-Chlorophenyl)piperazin-1- ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213)Journal of Medicinal Chemistry, 2001
- Receptor density as a factor governing the efficacy of the dopamine D4 receptor ligands, L‐745,870 and U‐101958 at human recombinant D4.4 receptors expressed in CHO cellsBritish Journal of Pharmacology, 1999
- 2,2-dicyanovinyl as a nonaromatic aryl bioisostere: synthesis, binding experiments and SAR studies of highly selective dopamine D4 receptor ligandsBioorganic & Medicinal Chemistry Letters, 1999
- NGD 94-1 as an agonist at human recombinant dopamine D4.4 receptors expressed in HEK293 cellsEuropean Journal of Pharmacology, 1999
- Azaindole derivatives with high affinity for the dopamine D4 receptor: Synthesis, ligand binding studies and comparison of molecular electrostatic potential mapsBioorganic & Medicinal Chemistry Letters, 1999
- 3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine: An Antagonist with High Affinity and Selectivity for the Human Dopamine D4 ReceptorJournal of Medicinal Chemistry, 1996