Chronic mucocutaneous moniliasis with impaired delayed hypersensitivity.

  • 1 March 1970
    • journal article
    • Vol. 6  (3) , 375-85
Abstract
Three patients, including two brothers, with chronic mucocutaneous moniliasis and endocrinopathy were evaluated from an immunological viewpoint. Each patient had defective delayed hypersensitivity to Candida albicans as manifested by a negative skin test and absent lymphocyte response after in vitro exposure to the antigen. Cutaneous responses to other antigens were intact, and there were no demonstrable abnormalities in humoral immunity. In one case, the in vitro lymphocyte response was restored following an injection of a leucocyte extract from a skin test positive subject, although the cutaneous lesions remained unchanged.