Plasma Levels of Clobazam after 10‐, 20‐, and 40‐mg Tablet Doses in Healthy Subjects

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Abstract
Substantial intersubject and intrasubject variation in the bioavailability of clobazam, an antianxiety drug, exists following ingestion of 10, 20 and 40 mg doses in 12 human volunteers. Peak concentrations and area under the plasma level-time curve were directly proportional to the dose of clobazam and the mean plasma half-life (t1/2) of clobazam was about 18 h regardless of dose administered. The t1/2 value was less than that previously reported, as the current results allow differentiation of parent drug from metabolites. This 18 h t1/2 compares favorably with the half-life of other benzodiazepines.