Pharmacoproteomics in drug development
- 1 January 2003
- journal article
- review article
- Published by Springer Nature in The Pharmacogenomics Journal
- Vol. 3 (2) , 69-76
- https://doi.org/10.1038/sj.tpj.6500164
Abstract
The field of proteomics is taking on increased significance as the relevance of investigating and understanding protein expression in disease and drug development is appreciated. Recent advances in proteomics have been driven by the availability of numerous annotated whole-genome sequences and a broad range of technological and bioinformatic developments that underscore the complexity of the proteome. This review briefly addresses some of the various technologies that comprise Expression Proteomics and Functional Proteomics, citing examples where these emerging approaches have been applied to pharmacology, toxicology, and the development of drugs.Keywords
This publication has 76 references indexed in Scilit:
- A proteomic view of the Plasmodium falciparum life cycleNature, 2002
- Comparative assessment of large-scale data sets of protein–protein interactionsNature, 2002
- Selective Detection of Membrane Proteins Without AntibodiesMolecular & Cellular Proteomics, 2002
- Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometryNature, 2002
- Functional organization of the yeast proteome by systematic analysis of protein complexesNature, 2002
- Directed Proteomic Analysis of the Human NucleolusCurrent Biology, 2002
- A comprehensive two-hybrid analysis to explore the yeast protein interactomeProceedings of the National Academy of Sciences, 2001
- Probability-based protein identification by searching sequence databases using mass spectrometry dataElectrophoresis, 1999
- An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein databaseJournal of the American Society for Mass Spectrometry, 1994
- A novel genetic system to detect protein–protein interactionsNature, 1989