Taxol, a microtubule stabilizing agent, blocks the replication of Trypanosoma cruzi.
- 1 July 1981
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 78 (7) , 4571-4575
- https://doi.org/10.1073/pnas.78.7.4571
Abstract
Taxol, an experimental antitumor agent and stabilizer of microtubules, inhibits in vitro replication of the human pathogenic hemoflagellate T. cruzi. Micromolar concentrations of the drug prevent the completion of cell division in these organisms but allow the multiplication of cell organelles such as the nucleus, kinetoplast and flagellum. The result is the formation of motile organisms that have extra organelles but cannot fully replicate. Division proceeds to a relatively fixed locus on the long axis of the organism, suggesting the presence of a specific affected structure or function at this site. Hypothetically, taxol produces these effects by stabilizing a portion of the microtubular cytoskeleton of T. cruzi.This publication has 9 references indexed in Scilit:
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