MUTAGENICITY TEST WITH SACCHARIN IN THE MALE-MOUSE
- 1 January 1979
- journal article
- research article
- Vol. 2 (4) , 1047-1053
Abstract
The ability of saccharin to induce chromosome aberrations in mammals was tested in male mice injected i.p. with 1, 2, or 4 g saccharin/kg body wt or receiving during a 100 day period 20 g of saccharin/l drinking water. Two tests on somatic cells, induction of chromosomal aberrations in bone marrow cells and of micronulcei in polychromatic erythrocytes, and 2 tests on germ cells, the spermatocyte test on treated males and the dominant lethality test, yielded all negative results. The positive findings reported in the literature were probably due to the mutagenic activity of saccharin impurities.This publication has 3 references indexed in Scilit:
- Saccharin-Induced Sister Chromatid Exchanges in Chinese Hamster and Human CellsScience, 1978
- Heritable chromosome aberrations in mammals after exposure to chemicalsRadiation and Environmental Biophysics, 1976
- The Micronucleus Test for Cytogenetic AnalysisPublished by Springer Nature ,1976